Endocrine Abstracts

Purpose: IGF receptor 1 (IGF1R) and epidermal growth factor receptor (EGFR) are receptors tyrosine-kinase (RTK) whose altered signaling are critical factors in development of many types of tumours. These RTK are some of the main targets of the microRNA miR-7. This important tumor supressor miRNA has the ability to inhibit the motility, invasiveness and anchorage-independent growth, suggesting a strong therapeutic potential in many types of cancer. Pituitary adenomas (PA) are a...

Hypothyroidism and autoimmune thyroiditis are common in patients with Down’ syndrome (DS), leading to common prescription of thyroid replacement therapy. On the other hand, thyroid function is involved in oxidative stress (OS) mechanisms. DS is a well-known high OS condition because several genes involved in OS mechanisms map on chromosome 21 and coenzyme Q10, lipophilic antioxidant, could be more correlated with hypothyroidism than TSH in DS people. To investigate relati...

Objective: To characterise insulinoma diagnosed and treated in the period 1983–2014 in various hospitals in Spain.Methods: Inclusion criteria were the presence of biochemical and morphological criteria compatible with insulinoma and/or histologic demonstration of tumour.Results: Twenty-nine patients (23 women (79.3%); mean age 48.7±17.4 years (range, 16–74)) were recruited. In 26 (89.7%) cases the tumor was sporadic ...

Introduction: Intraoperative identification of neck lesions in patients who have undergone previous neck surgery is particularly difficult, because of operative scarring and distorted anatomy. Radioguided occult lesion localisation (ROLL) involves the preoperative intratumoral ultrasound-guided injection of a radioactive tracer. In the present study, we investigated the efficacy of roll in two patients with papillary thyroid cancer (PTC) who underwent previous neck exploration...

Introduction: The syndrome of late-onset hypogonadism (LOH) is a clinical and biochemical syndrome associated with advancing age male, characterized by typical symptoms and decreased serum concentrations of testosterone, which can affect multiple organ systems and may impair quality of life. The prevalence of LOH syndrome is higher in certain patient groups, obese, diabetic and suffering from erectile dysfunction manifest LOH at higher rates than the general population.<p ...

Introduction: In 2004, the WHO defined atypical pituitary adenomas (APAs) those with Ki-67 >3%, excessive p53 expression and increased mitotic activity. The usefulness of this classification is still controversial.Aim: To compare the clinical and prognostic features in a series of typical and atypical pituitary adenomas.Materials and methods: We retrospectively reviewed 343 consecutive PAs. APAs represented 18.7% of the cases. ...

Anti-Mullerian hormone (AMH), a member of transforming growth factor β (TGF-β), shows different sex-related functions. In male, from the fetal development till the puberty, the expression of AMH by Sertoli cells causes regression of Mullerian ducts with subsequent testicular differentiation. Mainly studied in female, AMH produced by ovarian granulosa cells inhibits both initiation of primordial follicle growth and the FSH-stimulated follicle growth. Moreover, recent ...

Introduction: Although in females of infertile couples abnormal PRL has a definitive role in the medical flow-chart, its role in males is less clear. Animal models suggest that PRL does not play a major role in male reproduction, although its trophic action on male accessory glands was often observed. Studies in humans are scanty. We systematically evaluated possible clinical and ultrasound correlates of PRL in males of infertile couples.Methods: Out of ...

Background: Type 2 diabetes and Hipertension are common in obese patients. Bariatric surgery is effective in sustained weight loss, but also improves glycemic and hypertension control. A high percentage of diabetes remission occurs.Methods: Retrospective study of type 2 diabetic patients submitted to bariatric surgery between 2006 and 2013 in a central hospital. Primary endpoint was evaluation of diabetes and hypertension remission, 2 years after surgery...

Introduction: The role of testosterone supplementation (TS) as a possible treatment for male sexual dysfunction remains questionable. The aim of the present study is to meta-analyse data evaluating the effects of TS on male sexual function and its therapeutic synergism with the use of phosphodiesterase type 5 (PDE5i).Methods: An extensive Medline Embase and Cochrane search was performed including the following words: ‘testosterone’, ‘erect...